Nepalganj is a town in Nepal, located in the Banke district of the Bheri region (Terai), near Nepal's southern border with India. It has a population of 60,000 people and is the transport hub for western Nepal.

In the middle of town lies Birendra Chowk, an intersection named for the late king, of whom it has a statue. From Birendra Chowk, the airport is 6km north. The name of the airport is Mahendra Airport, named after the name of Late King Mahendra. The major places in Nepalgunj are Gharbaritole, Ganeshpur, Sadar Line, Koreanpur, Belaspur, B.P. Chowk. There are many private owned high schools in this part of Nepal. The oldest one among them is Angels High School situated in Gharbaritole. It has Medical college along with other colleges. It also has good facilities for lodging and eating. It connects under developed part of Nepal as Dolpa, Jumla, Mugu via airways.

The border crossing, 6 km south of Nepalganj, is one of a limited number of places where non-Indian foreigners are allowed to cross the border with India.